Sperm-like Nanocarriers for Ultrafast Delivery of Antisense DNA - Nanoscale (RSC Publishing)

Although various nanomaterials have been designed as intracellular delivery tools, the following aspects have become obstacles to limit its development, like complex and time-consuming synthesis process, as well as relatively limited application areas (i.e. biosensing or cell imaging). Here, we developed a novel nano-delivery system called “nano-sperm” with low cytotoxicity and high biocompatibility. In this system, we use DNA oligonucleotides as backbone to synthesize the nanostructure with silver nanoclusters in the head and functional fragments in the tail, which is shaped like a sperm, to achieve dual functions of ultrafast delivery and imaging/therapy. As a model, we analyzed the possibility of “nano-sperm” to carry DNA with different structures for imaging or survivin-asDNA for tumor therapy. Therefore, this work constitutes a novel bifunctional high-speed delivery vehicle, which successfully fills the gap in the field of tumor therapy using DNA-templated nanoclusters as a delivery vehicle.

Supplementary files

X. Tang, T. Chen, H. Chen, S. Yu, S. Cao, C. Liu, Y. Ma, F. Sun, Q. Pan and X. Zhu, Nanoscale, 2022, Accepted Manuscript , DOI: 10.1039/D2NR02050E

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