Architecture of the tail drives sperm forward
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June 30, 2022
Architecture of the tail drives sperm forward
by Bill Hathaway, Yale University
Channels that line the tail of sperm contain pores that allow the entry of calcium, which fuels their journey to the female reproductive tract.
In a new study, researchers from Yale and the University of Texas Southwestern captured images of critical components of these so-called CatSper ion channels, revealing that they are interconnected and arranged in zig-zag fashion. This molecular architecture allows for the highly coordinated whip-like action of the sperm tail that propels it to its goal, they report in the journal Nature Communications.
"The subunits of these channels are arranged like staggered beads on a necklace in a double row," said Jean-Ju Chung, associate professor of cellular and molecular physiology at Yale and co-corresponding author of the research.
Chung and her Yale colleagues had previously identified the CatSper channel complex, which is linearly arranged along the flagella of sperm, as the primary driver of sperm's hyperactivated motility. The use of cryo-electron tomography allowed researchers in the new study to view the channel complex at the atomic level, revealing an important glimpse of the complex relationship of components along the channels which are essential to jumpstarting life in mammals.
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